REFEREE 1 Major Concerns
نویسندگان
چکیده
Anil N Makam ([email protected]) Holly J Lanham ([email protected]) Kim Batchelor ([email protected]) Lipika Samal ([email protected]) Brett Moran ([email protected]) Temple Howell-Stampley ([email protected]) Lynne Kirk ([email protected]) Manjula Cherukuri ([email protected]) Noel Santini ([email protected]) Luci K Leykum ([email protected]) Ethan A Halm ([email protected])
منابع مشابه
cAMP/PKA signaling reinforces the LATS-YAP pathway to fully suppress YAP in response to actin cytoskeletal changes
As you can see from their comments, while referee #1 is rather negative towards your study, referees #2 and #3 are very supportive of its publication and agree on the high potential interest of your findings. In general, although they believe that the evidence presented properly supports your conclusions, some technical concerns have arisen with which you will have to deal before your manuscrip...
متن کاملTriggered Ca 2 + influx is required for extended - synaptotagmin 1 - induced ER - plasma membrane
As you will see, while the referees consider that your study deepens our knowledge on the regulation of E-Syt1, they also raise several concerns and think that some of your conclusions are not sufficiently supported by the data provided. I won't list all concerns here, as all reports are very constructive and clear. Essentially, more insight and controls regarding the calcium-mediated regulatio...
متن کاملQuantitative modeling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease
Three referees have now evaluated the manuscript, and their comments are shown below. As you will see, while referees 2 and 3 are more positive and would support publication here after appropriate revision referee 1 is not in favour of publication of the study here. Essentially, he/she raises two types of concerns: issues regarding the physiological significance of and the conceptual advance pr...
متن کاملQuantitative proteomics of the integrin adhesome reveals a myosin II-dependent recruitment of LIM domain proteins
Referee 1's main concerns are with regard to the presentation of the data, which in his/her opinion would benefit from additional clarifications and/or reorganization in several instances. Referee 2 feels that additional evidence is needed to substantiate the idea that LIM-domain containing proteins depend on myosin II for recruitment to focal adhesions and s/he proposes several ways on how thi...
متن کاملThe Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK
The feedback we have now received, I am afraid to say, provides insufficient support for us to consider this study further for publication. While referee 1 is cautiously leaning to a more favorably recommendation, both referees 2 and 3 indicate major reservations. These are based on a number of specific concerns with the experimental evidence and its presentation, which I will not repeat in det...
متن کاملRITA , a novel modulator of Notch signaling , acts via nuclear export of RBP - J
Thank you for submitting your manuscript for consideration by the EMBO Journal. It has now been seen by three referees whose comments are enclosed. As you will see, all three reviewers express significant interest in your work and are broadly in favour of publication, pending satisfactory revision. The major issue expressed to varying degrees by all the referees concerns the characterisation of...
متن کامل